Negative-pressure isolators, also known as closed-system isolators (CSIs), are engineered for the safe preparation of hazardous drugs and sterile products under strict containment. These systems maintain a negative-pressure environment to prevent exposure, integrate HEPA-filtered airflows to protect the product, and often meet the requirements of standards such as USP , USP and ISO 14644‑1.
Our product range includes isolators with glove-port access, pass-through chambers, integrated monitoring systems, solvent-resistant construction, and configurable sizes to fit compounding pharmacies, hospital cleanrooms and GMP production suites. Whether your workflow involves cytotoxic agents, biologics or sensitive sterile compounding, we offer turn-key solutions that streamline validation, maintenance and operator ergonomics.
Choosing the right isolator involves more than selecting a footprint — it means understanding your containment class, workflow, transfer requirements, glove-port ergonomics, decontamination cycles, and service access. At ARES Scientific, we guide you through factors like exhaust ducting, pressure-decay monitoring, filter change protocols and audit-ready documentation to ensure compliance with both regulatory and operational demands.
A negative-pressure isolator is designed so that all work occurs in a sealed, controlled environment maintained at a negative pressure relative to the surrounding room. This containment prevents hazardous drug vapors or particulates from escaping into the lab environment. It is most appropriate for sterile hazardous-drug compounding and containment operations.
These systems typically require validation upon installation, after any relocation or major repair, and at least annually thereafter. Certification includes tests for pressure decay, filter integrity, glove-port leak checks, and airflow containment verification.
Many sterile compounding environments demand an ISO Class 5 (or better) work zone for the product, while the isolator structure maintains negative pressure for operator and environmental protection. Always verify local regulatory requirements and performance certification data.
Yes — many modern isolators offer automated vial-handling, integrated robotics, barcode scanning, and software-controlled chambers. When designing for automation, be sure to consider glove-port layout, transfer-chamber size and service access for cleaning and maintenance.
